Vishnu Dileep, Ph.D.
My research aims to understand the genomic and epigenomic changes that underlie brain function and dysfunction. I am a postdoctoral fellow (NIH K99/R00) in Prof. Li-Huei Tsai's lab at the Massachusetts Institute of Technology.
My postdoctoral research explored the impact of DNA double-stranded breaks on the genome organization in neurodegeneration. Prior to this, I did my doctoral research at Florida State University, where I studied the relationship between 3D genome organization and DNA replication.
Highlighted Publications
† Co-corresponding, * Co-first authorship
Dileep V †*, Boix CA*, Mathys H, Marco A, Welch GM, Meharena HS, Loon A, Jeloka R, Peng Z, Bennett DA, Kellis M†, Tsai LH †. Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell (2023) [PDF]
Dileep V*, Wilson K*, Marchal C, Lyu X, Zhao PA, Li B, Axel P, Bartlett DA, Qin Z, Robins AJ, Schulz TC, Kulik KJ, Dalton S, Corces VG, Gilbert DM. Rapid lineage determination of human embryonic stem cells is accompanied by discordant changes in replication timing and chromatin compartment. Stem Cell Reports (2019) [PDF]
Dileep V, Gilbert DM. Single-cell replication profiling reveals stochastic regulation of the mammalian replication-timing program. Nature Communication (2018) [PDF]
Dixon J†*, Xu J*, Dileep V*, Zhan Y*, Song F*, Le VT, Yardimci GG, Chakraborty A, Bann DV, Wang Y, Clark R, Zhang L, Yang H, Liu T, Iyyanki S, An L, Pool C, Sasaki T, Rivera-Mulia JC, …, Ay F†, Noble WS†, Dekker J†, Gilbert DM†, Yue F†. Integrative detection and analysis of structural variation in cancer genomes. Nature Genetics(2018) [PDF]
Dileep V, Ay F, Sima J, Vera DL, Noble WS, Gilbert DM. Topologically-associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication timing program. Genome Research (2015) [PDF]
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Dileep, et al. Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell (2023)
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Dileep, et al. Rapid lineage determination of human embryonic stem cells is accompanied by discordant changes in replication timing and chromatin compartment. Stem Cell Reports (2019)
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Dileep V & Gilbert DM. Single-cell replication profiling reveals stochastic regulation of the mammalian replication-timing program. Nature Communication (2018)
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Dileep, et al. Topologically-associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication timing program. Genome Research (2015)
